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Ghori, Syed Safiullah
- Anticonvulsant Activity of Leaf Extracts of Anacardium occidentale. Linn
Authors
1 Department of Pharmacology, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad – 500001, IN
2 Anwarul-Uloom College of Pharmacy, New Mallepally, Hyderabad – 500001, Andhra Pradesh, IN
3 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia – Serdang 43400, Selangor Darul Ehsan, MY
4 Anwarul-Uloom College of Pharmacy, New Mallepally, Hyderabad–500001, Andhra Pradesh, IN
5 Bharat Institute of Technology, Ibrahimpatnam, RR. Dist., Hyderabad - 500001. Andhra Pradesh, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 2 (2011), Pagination: 72-76Abstract
The aim of the present study was to investigate the anticonvulsant effect of methanolic and aqueous extracts of the leaves of Anacardium occidentale Linn. on electrically and chemically induced seizures. The methanolic and aqueous extracts of the leaves of A. occidentale (250 and 500 mg/kg.b.w. p.o.) were studied for the anticonvulsant effect on Maximum electroshock (MES) and Pentylene tetrazole (PTZ) induced convulsions in mice. The latency of onset of tonic-clonic convulsions and the number of animals protected from tonic convulsions were noted. AOMEE and AOAQE (500 mg/kg.b.w.p.o) significantly reduced the onset and duration of seizures induced by maximal electroshock (MES). The same dose also protected animals from pentylene tetrazole-induced tonic seizures and significantly delayed the onset of tonic seizures.Keywords
Anacardium occidentale, Anticonvulsant Activity, MES and PTZ Induced Convulsions.References
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- Wound Healing Activity of Poly Herbal Formulation
Authors
1 Pharmacology Research Lab, Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad-50001, Telangana, IN
2 Almocare Herbal and Ayurvedic Clinic, Chirag Ali lane, Abids, Hyderabad, Telangana, IN
3 Department of Pharmaceutics, Anwarululoom College of Pharmacy, New Mallepally, Hyderabad-50001, Telangana, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 7, No 2 (2015), Pagination: 125-128Abstract
Aim: To evaluate the Wound healing potential of a Poly herbal formulation.
Material and Methods: In the present work a poly herbal Unani formulation; beeswax (base), sesame oil (10%), olive oil (10%), honey (20%), psoraleac (5%), borax (10%), arnica (5%) and curcuma longa (1%) were used and the wound healing potential was determined by both excision and incision wound healing models. Albino wistar rats were used for this purpose. The wound area in excision wound model and tensile strength in incision wound model were determined. Histopathological studies were also carried out to determine the phases of wound healing.
Results: From the results obtained it was evident that the PUF has shown wound healing activity in both excision and incision wound models. In the EWM the beneficial effect of the PUF was evident from the day of first measurement as the progressive decrease in wound area was observed. On the 2nd day of wounding, the wound area shrinkage in 10% formulation treated group was more when compared to the other test groups. The wound area was decreasing constantly and predominantly in all test treated groups as compared to the negative control group. In the IWM there was decrease in tensile strength of the animals treated with the 10% formulation and was comparable with the standard group. In the histopathological examination, the phases in the wound healing process were observed and it showed that proliferation phase was the predominant stage of action of PUF. The best re-modeling, particularly, re-epithelization were detected with the 10% formulation group On the other hand; faster keratinization characterized with minor intraepithelial cornification was seen in 15% group.